Simple and sensitive HPLC determination of paracetamol and theophylline in fresh and powdered milk

Poster presented at the 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. 4-7 April 2016, Glasgow, UKN/

Milk as a drug delivery platform in paediatrics

Communication presented at the PSSRC − 9th Annual Symposium. 16-18 September 2015, Ghent, Belgium"Purpose: to assess the physical properties of spray dried milk powders and evaluate drug-milk interactions.

Medicinal powders made of fresh milk for pediatric use

Communication presented at the 1st International Congress of CiiEM - From Basic Sciences to Clinical Research. 27-28 November 2015, Egas Moniz, Caparica, Portugal"Nowadays, the need to formulate medicines specifically designed for children is imperative [1] and solid dosage forms are the first choice for providing the required drug stability and dose accuracy. Milk, as a worldwide accepted food, is proposed in this study as a platform to deliver drugs orally in pediatrics. Therefore, the main goals of this project are: (a) to assess the properties of spray-dried milk powders, (b) to evaluate drug-milk interactions and (c) to ascertain the stability of the spray-dried milk powders."Fundação para a Ciência e a Tecnologi

Gait maturation in children with cerebral palsy: A pilot study

This study aimed at observing children with cerebral palsy's (CP) gait maturation and to correlate gait maturation's motor skill parameters. Podogram and video shooting of eight children's gait were used. Children up to seven years of age participated in the study. Cluster analysis was applied, dividing the sample into two groups, using the relation between pelvis’ width and the spreading of the ankles (REL) as parameters. Data were analyzed using t-test, analysis of Deltas, and Pearson’s correlation. Deviance from normality for all the parameters was demonstrated with greater failure in speed and cadence and a significant correlation among these parameters, and yet between them and the REL parameter. Although children with CP had acquired gait, they still do it immaturely

Persistence in the zero-temperature dynamics of the QQ-states Potts model on undirected-directed Barab\'asi-Albert networks and Erd\"os-R\'enyi random graphs

The zero-temperature Glauber dynamics is used to investigate the persistence probability $P(t)$ in the Potts model with $Q=3,4,5,7,9,12,24,64, 128$, $256, 512, 1024,4096,16384$,..., $2^{30}$ states on {\it directed} and {\it undirected} Barab\'asi-Albert networks and Erd\"os-R\'enyi random graphs. In this model it is found that $P(t)$ decays exponentially to zero in short times for {\it directed} and {\it undirected} Erd\"os-R\'enyi random graphs. For {\it directed} and {\it undirected} Barab\'asi-Albert networks, in contrast it decays exponentially to a constant value for long times, i.e, $P(\infty)$ is different from zero for all $Q$ values (here studied) from $Q=3,4,5,..., 2^{30}$; this shows "blocking" for all these $Q$ values. Except that for $Q=2^{30}$ in the {\it undirected} case $P(t)$ tends exponentially to zero; this could be just a finite-size effect since in the other "blocking" cases you may have only a few unchanged spins.Comment: 14 pages, 8 figures for IJM

Grids of stellar evolution models for asteroseismology (CESAM + POSC)

In this paper we present a grid of stellar evolution models, computed with an up-to-date physical description of the internal structure, using the Code d'Evolution Stellaire Adaptatif et Modulaire (CESAM). The evolutionary sequences span from the pre-main sequence to the beginning of the Red Giant Branch and cover an interval of mass typical for low and intermediate mass stars. The chemical composition (both helium and metal abundance) is the solar one. The frequencies of oscillation, computed for specific stellar models of the grid using the Porto Oscillations Code (POSC), are also provided. This work was accomplished in order to support the preparation of the CoRoT mission within the Evolution and Seismic Tools Activity (CoRoT/ESTA). On the other hand, the grid can also be used, more generally, to interpret the observational properties of either individual stars or stellar populations. The grids (data and documentation) can be found at http://www.astro.up.pt/corot/models/cesamComment: Paper accepted for publication by Astrophysics and Space Scienc

Spray-dried fresh milk powders for oral drug delivery in pediatrics

Poster presented at the 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. 4-7 April 2016, Glasgow, UKN/